UBR1

Across TCGA cell cohorts, UBR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,808 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBR1-associated GO terms across cancer lineages are Ubiquitin-dependent protein catabolic process via the N-end rule pathway, Cytosolic transport, and Viral translational termination-reinitiation. Each is linked with UBR1 in more than 19 cancer types. Because this analysis shows association rather than direction, both UBR1-to-partner and partner-to-UBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ubiquitin-dependent protein catabolic process via the N-end rule pathway grouped by UBR1-low versus UBR1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR1→partner) and Y-score (partner→UBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.117	+1.045	<.001	<.001	3	20
STOMACH	Cytosolic transport →	+0.072	+0.888	.004	.003	3	16
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.094	+0.814	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Microtubule polymerization →	+0.133	+0.961	.003	.001	3	15
BREAST	Golgi vesicle transport →	+0.065	+0.764	<.001	<.001	3	15
BLOOD_Lymphoma	Regulation of translational initiation →	+0.089	+0.829	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,808 associations by consensus.

Ubiquitin-dependent protein catabolic process via the N-end rule pathway by UBR1 expression — LIVER

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