UBR1

Across TCGA cell cohorts, UBR1 mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBR1-associated genes across cancer lineages are CPXCR1, ANKRD66, and TRAT1. Each is linked with UBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBR1-to-partner and partner-to-UBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPXCR1 grouped by UBR1-low versus UBR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR1→partner) and Y-score (partner→UBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPXCR1 →	+0.051	+4.234	.008	<.001	3	2
BREAST	ANKRD66 →	+0.030	+5.781	<.001	.001	3	2
OVARY	TRAT1 →	+0.017	+4.029	.005	.009	3	2
CNS	ETDC →	+1.024	+4.169	<.001	.008	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

CPXCR1 by UBR1 expression — BLOOD_Leukemia

Explore this box plot interactively →