UBQLN1

Across TCGA patient cohorts, UBQLN1 mutation is significantly associated with the RNA expression of many other genes, with 2,009 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBQLN1-associated genes across cancer lineages are CYLC1, ATP5F1A, and SKA1. Each is linked with UBQLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLN1-to-partner and partner-to-UBQLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYLC1 grouped by UBQLN1-low versus UBQLN1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLN1→partner) and Y-score (partner→UBQLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CYLC1 →	+0.021	+4.884	<.001	.004	3	2
UCEC	ATP5F1A →	+0.417	+2.190	.005	.008	3	2
UCEC	SKA1 →	+0.709	+2.332	<.001	<.001	3	2
UCEC	BUB1B →	+0.631	+2.332	.007	<.001	3	2
UCEC	CHAF1B →	+0.547	+2.431	.002	.001	3	2
UCEC	PKN3 →	+0.629	+2.732	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,009 associations by consensus.

CYLC1 by UBQLN1 expression — SKCM

Explore this box plot interactively →