UBQLN1

Across TCGA pan-cancer cohorts, UBQLN1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated UBQLN1 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UBQLN1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBQLN1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

ACC, KIRC, and LUAD are the cancer types where UBQLN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.385	0.762	<.001	72	view →
KIRC	DFS	Tertile	All	0.739	0.549	<.001	61	view →
LUAD	OS	Tertile	All	0.741	0.851	.004	57	view →
BLCA	DFS	Tertile	II,III,IV	0.444	0.571	.007	36	view →
HNSC	OS	Quartile	All	0.584	0.793	.006	28	view →
MESO	DFS	Median	IV	0.189	0.521	.002	25	view →
PAAD	OS	Tertile	All	0.238	0.676	<.001	24	view →
LIHC	DFS	Median	All	0.483	0.601	.003	17	view →
SKCM	DFS	Median	All	0.774	0.676	.005	14	view →
LUSC	OS	Median	II,III,IV	0.808	0.675	.002	14	view →
UVM	DFS	Tertile	III,IV	0.273	0.780	.019	12	view →
BRCA	OS	Quartile	IV	0.917	0.239	.002	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

UBQLN1–ACC (DFS)

Open the ACC breakdown →