UBQLN1

Across TCGA patient cohorts, UBQLN1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBQLN1-associated genes across cancer lineages are PRDX1, Shc_pY317, and c-Jun_pS73. Each is linked with UBQLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLN1-to-partner and partner-to-UBQLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by UBQLN1-low versus UBQLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLN1→partner) and Y-score (partner→UBQLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.178	+2.321	.027	.033	3	2
COAD	Shc_pY317 →	-0.229	-2.987	.008	.035	3	2
COAD	c-Jun_pS73 →	-0.227	-2.957	.005	.036	3	2
UCEC	C-Raf →	+0.148	+2.807	.008	.003	3	2
COAD	EGFR_pY1068 →	-0.464	-2.991	.006	.036	2	2
UCEC	ERK2 →	+0.230	+2.807	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PRDX1 by UBQLN1 expression — UCEC

Explore this box plot interactively →