UBQLN1

Across TCGA cell cohorts, UBQLN1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBQLN1-associated genes across cancer lineages are ARGFX, MAGEB4, and OR4F15. Each is linked with UBQLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLN1-to-partner and partner-to-UBQLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by UBQLN1-low versus UBQLN1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLN1→partner) and Y-score (partner→UBQLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ARGFX →	+0.035	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	MAGEB4 →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	OR4F15 →	+0.006	+3.240	.008	.004	3	1
LARGE_INTESTINE	TBX5 →	+0.182	+3.555	.008	.003	3	1
BREAST	SIGLECL1 →	+0.026	+5.781	<.001	.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.537	+3.252	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ARGFX by UBQLN1 expression — OVARY

Explore this box plot interactively →