Across TCGA pan-cancer cohorts, UBL5 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated UBL5 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher UBL5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBL5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and CHOL show a favorable association.

KICH, UVM, and ESCA are the cancer types where UBL5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.308	0.942	.001	103	view →
UVM	DFS	Tertile	II,III,IV	0.307	0.709	.001	65	view →
ESCA	DFS	Median	II,III,IV	0.380	0.599	.001	49	view →
ACC	DFS	Median	All	0.271	0.640	<.001	44	view →
LGG	DFS	Median	All	0.666	0.801	<.001	33	view →
UCS	DFS	Tertile	IV	0.239	0.942	.024	30	view →
BLCA	DFS	Quartile	II,III,IV	0.609	0.407	.007	29	view →
CHOL	OS	Tertile	II,III,IV	0.829	0.274	.003	24	view →
SKCM	DFS	Quartile	II,III,IV	0.517	0.885	<.001	22	view →
LAML	DFS	Tertile	All	0.419	0.698	.002	16	view →
LIHC	OS	Median	III,IV	0.186	0.513	<.001	15	view →
READ	OS	Median	IV	0.510	0.932	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

Exploration

Same gene, other analysis: UBL5 tumor-vs-normal RNA expression · all UBL5 data types