UBL4A

Across TCGA pan-cancer cohorts, UBL4A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBL4A data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UBL4A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UBL4A expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where UBL4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.911	.012	42	view →
CCRCC	DFS	Tertile	IV	0.861	0.137	.024	12	view →
PDAC	OS	Median	IV	0.491	0.836	.024	9	view →
LSCC	DFS	Tertile	All	0.836	0.592	.018	5	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	3	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBL4A–COAD (DFS)

Open the COAD breakdown →