UBL3

Across TCGA patient cohorts, UBL3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBL3-associated genes across cancer lineages are p70-S6K_pT389, 14-3-3_beta, and EGFR_pY1068. Each is linked with UBL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBL3-to-partner and partner-to-UBL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by UBL3-low versus UBL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBL3→partner) and Y-score (partner→UBL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.225	-3.321	.006	.009	3	2
UCEC	14-3-3_beta →	-0.134	-3.143	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.346	-2.807	.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.156	-3.459	.002	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.126	-1.990	.021	.030	3	1
UCEC	ACC_pS79 →	+0.340	+2.115	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p70-S6K_pT389 by UBL3 expression — UCEC

Explore this box plot interactively →