UBL3

Across TCGA pan-cancer cohorts, UBL3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UBL3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBL3 RNA is repressed in tumor relative to normal tissue. In most cancer types UBL3 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and UCEC are the cancer types where UBL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−1.044	<.001	10	view →
LUAD	Female	III,IV	−1.491	<.001	9	view →
UCEC	All	All	−1.568	<.001	8	view →
KIRC	Male	II,III,IV	−0.635	<.001	8	view →
LUSC	Female	II,III,IV	−2.455	<.001	7	view →
STAD	All	IV	−0.976	.007	7	view →
COAD	Female	All	−1.038	<.001	6	view →
KIRP	All	All	−0.581	<.001	6	view →
THCA	Male	II,III,IV	−0.504	.019	5	view →
READ	All	All	−0.833	.004	4	view →
BLCA	All	All	−0.591	.006	4	view →
ESCA	Male	All	−1.030	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UBL3–HNSC

Open the HNSC breakdown →