UBFD1

Across TCGA patient cohorts, UBFD1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBFD1-associated genes across cancer lineages are ATM, Notch1, and Rad50. Each is linked with UBFD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBFD1-to-partner and partner-to-UBFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UBFD1-low versus UBFD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBFD1→partner) and Y-score (partner→UBFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.755	-3.169	<.001	<.001	3	3
UCEC	Notch1 →	+0.186	+2.128	<.001	.009	3	2
UCEC	Rad50 →	-0.243	-2.502	.010	.002	3	2
UCEC	VHL →	-1.034	-2.000	<.001	.010	3	2
UCEC	ASNS →	+0.332	+2.459	.019	.019	3	2
UCEC	c-Met_pY1235 →	+0.073	+2.232	.011	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by UBFD1 expression — UCEC

Explore this box plot interactively →