UBE4B

Across TCGA patient cohorts, UBE4B mutation is significantly associated with the RNA expression of many other genes, with 5,021 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE4B-associated genes across cancer lineages are CFTR, NDUFB6, and TYMSOS. Each is linked with UBE4B in more than 3 cancer types. Because this analysis shows association rather than direction, both UBE4B-to-partner and partner-to-UBE4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFTR grouped by UBE4B-low versus UBE4B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE4B→partner) and Y-score (partner→UBE4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CFTR →	-2.050	-3.459	<.001	.005	3	4
UCEC	NDUFB6 →	+0.475	+2.180	<.001	.001	3	4
UCEC	TYMSOS →	+0.776	+1.890	<.001	<.001	3	4
UCEC	RFC5 →	+0.469	+1.475	<.001	.003	3	4
UCEC	ATP5IF1 →	+0.402	+1.879	<.001	<.001	3	4
UCEC	C12orf65 →	+0.350	+1.723	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,021 associations by consensus.

CFTR by UBE4B expression — STAD

Explore this box plot interactively →