UBE3D

Across TCGA patient cohorts, UBE3D mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE3D-associated genes across cancer lineages are eIF4E, Tuberin_pT1462, and Cyclin-B1. Each is linked with UBE3D in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE3D-to-partner and partner-to-UBE3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by UBE3D-low versus UBE3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3D→partner) and Y-score (partner→UBE3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.179	+1.906	.034	.016	3	2
UCEC	Tuberin_pT1462 →	+0.279	+2.321	.002	.033	3	2
UCEC	Cyclin-B1 →	+0.596	+2.415	.008	.003	3	2
UCEC	INPP4B →	-0.349	-3.700	.007	.001	3	1
UCEC	JNK2 →	+0.224	+2.415	.005	.003	3	1
UCEC	Ku80 →	+0.232	+2.331	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by UBE3D expression — UCEC

Explore this box plot interactively →