UBE3D

Across TCGA cell cohorts, UBE3D mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible UBE3D-associated genes across cancer lineages are MT1B, GSTA5, and OR2M5. Each is linked with UBE3D in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE3D-to-partner and partner-to-UBE3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1B grouped by UBE3D-low versus UBE3D-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3D→partner) and Y-score (partner→UBE3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MT1B →	+0.136	+4.930	<.001	.008	3	1
SOFT_TISSUE	GSTA5 →	+0.021	+4.930	.001	.008	3	1
LARGE_INTESTINE	OR2M5 →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.024	+5.562	<.001	<.001	3	1
LUNG_SCLC	RBMY1F →	+0.626	+4.058	.001	.007	3	1
LUNG_SCLC	OR10A6 →	+0.013	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MT1B by UBE3D expression — SOFT_TISSUE

Explore this box plot interactively →