UBE3B

Across TCGA pan-cancer cohorts, UBE3B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UBE3B data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UBE3B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE3B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where UBE3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.543	1.000	.022	16	view →
CCRCC	OS	Quartile	II,III,IV	0.526	0.941	.001	8	view →
LSCC	OS	Median	All	1.000	0.920	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UBE3B–UCEC (DFS)

Open the UCEC breakdown →