UBE3B

Across TCGA pan-cancer cohorts, UBE3B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UBE3B’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where UBE3B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE3B is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

LIHC, HNSC, and THCA are the cancer types where UBE3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.965	<.001	9	view →
HNSC	All	II,III,IV	+0.334	.002	7	view →
THCA	All	All	−0.262	.001	6	view →
BRCA	All	II,III,IV	+0.177	.005	6	view →
COAD	All	All	−0.218	.002	5	view →
CHOL	Male	All	+1.609	<.001	3	view →
STAD	Male	III,IV	+0.883	.032	2	view →
KIRP	Female	II,III,IV	+0.479	.029	2	view →
UCEC	All	All	−0.343	.037	2	view →
BLCA	Female	III,IV	+0.375	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UBE3B–LIHC

Open the LIHC breakdown →