UBE3B

Across TCGA patient cohorts, UBE3B protein abundance is significantly associated with the RNA expression of many other genes, with 8,961 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible UBE3B-associated genes across cancer lineages are TMBIM6, COQ5, and COPZ1. Each is linked with UBE3B in more than 4 cancer types. Because this analysis shows association rather than direction, both UBE3B-to-partner and partner-to-UBE3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UBE3B versus TMBIM6 in BRCA, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3B→partner) and Y-score (partner→UBE3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMBIM6 →	+0.485	+0.300	<.001	<.001	3	5
BRCA	COQ5 →	+0.304	+0.214	<.001	<.001	3	4
LUAD	COPZ1 →	+0.376	+0.252	<.001	<.001	3	4
BRCA	HMGCL →	+0.704	+0.340	<.001	<.001	3	4
BRCA	SUDS3 →	+0.406	+0.229	<.001	<.001	3	4
BRCA	ARL1 →	+0.458	+0.299	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,961 associations by consensus.

UBE3B vs TMBIM6 — BRCA

Explore this scatter interactively →