UBE3B

Across TCGA patient cohorts, UBE3B mutation is significantly associated with the RNA expression of many other genes, with 3,970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE3B-associated genes across cancer lineages are ING2, CKAP2L, and SPATA5L1. Each is linked with UBE3B in more than 3 cancer types. Because this analysis shows association rather than direction, both UBE3B-to-partner and partner-to-UBE3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ING2 grouped by UBE3B-low versus UBE3B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3B→partner) and Y-score (partner→UBE3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ING2 →	+0.534	+3.182	.001	.009	3	4
UCEC	CKAP2L →	+0.506	+2.392	<.001	<.001	3	4
UCEC	SPATA5L1 →	+0.333	+1.602	.001	.002	3	4
UCEC	MCM6 →	+0.461	+2.662	.001	<.001	3	4
UCEC	OIP5 →	+0.591	+1.565	<.001	<.001	3	4
UCEC	NEIL3 →	+0.439	+2.269	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,970 associations by consensus.

ING2 by UBE3B expression — STAD

Explore this box plot interactively →