UBE3B

Across TCGA cell cohorts, UBE3B mutation is significantly associated with the RNA expression of many other genes, with 414 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE3B-associated genes across cancer lineages are WRAP73, ALKBH7, and GID4. Each is linked with UBE3B in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE3B-to-partner and partner-to-UBE3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WRAP73 grouped by UBE3B-low versus UBE3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3B→partner) and Y-score (partner→UBE3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WRAP73 →	+0.583	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ALKBH7 →	+0.450	+3.743	.001	<.001	3	2
LARGE_INTESTINE	GID4 →	+0.465	+3.237	.007	.003	3	2
LARGE_INTESTINE	CENPV →	+0.956	+3.237	.006	.003	3	2
LARGE_INTESTINE	GEMIN4 →	+0.559	+3.169	.005	.006	3	2
LARGE_INTESTINE	MAPT →	+1.374	+2.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 414 associations by consensus.

WRAP73 by UBE3B expression — LARGE_INTESTINE

Explore this box plot interactively →