UBE3A

Across TCGA pan-cancer cohorts, UBE3A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBE3A data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher UBE3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UBE3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

BRCA, HNSC, and UCEC are the cancer types where UBE3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.595	0.924	<.001	29	view →
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
UCEC	DFS	Median	All	0.914	0.614	.013	14	view →
SKCM	DFS	Median	All	0.461	0.759	.026	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUSC	DFS	Median	All	1.000	0.752	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBE3A–BRCA (OS)

Open the BRCA breakdown →