UBE3A

Across TCGA pan-cancer cohorts, UBE3A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UBE3A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UBE3A RNA is repressed in tumor relative to normal tissue. In most cancer types UBE3A is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where UBE3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.488	<.001	8	view →
LIHC	All	All	+0.346	<.001	7	view →
HNSC	All	II,III,IV	+0.328	.004	6	view →
CHOL	All	All	+1.060	<.001	5	view →
LUSC	Male	All	+0.375	<.001	5	view →
UCEC	All	All	−0.670	.001	2	view →
KICH	All	All	−0.326	.048	1	view →
LUAD	Female	II,III,IV	−0.325	.031	1	view →
KIRP	Male	All	−0.300	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UBE3A–THCA

Open the THCA breakdown →