UBE3A

Across TCGA pan-cancer cohorts, UBE3A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBE3A data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBE3A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBE3A expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, LSCC, and UCEC are the cancer types where UBE3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.132	1.000	.010	54	view →
LSCC	DFS	Median	All	0.838	0.586	.001	13	view →
UCEC	OS	Median	All	0.980	0.847	.006	10	view →
GBM	DFS	Tertile	All	0.446	0.264	.031	4	view →
PDAC	DFS	Median	III,IV	0.905	0.567	.024	3	view →
CCRCC	DFS	Tertile	II,III,IV	0.784	0.260	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBE3A–HNSC (OS)

Open the HNSC breakdown →