UBE3A

Across TCGA patient cohorts, UBE3A protein abundance is significantly associated with the RNA expression of many other genes, with 11,884 significant associations in total. GBM shows the largest number of these associations.

The most reproducible UBE3A-associated genes across cancer lineages are RTF1, TUBGCP4, and ZSCAN29. Each is linked with UBE3A in more than 6 cancer types. Because this analysis shows association rather than direction, both UBE3A-to-partner and partner-to-UBE3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UBE3A versus RTF1 in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3A→partner) and Y-score (partner→UBE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RTF1 →	+0.369	+0.171	<.001	<.001	3	7
LSCC	TUBGCP4 →	+0.469	+0.174	<.001	<.001	3	7
LSCC	ZSCAN29 →	+0.453	+0.226	<.001	<.001	3	6
BRCA	FAN1 →	+0.497	+0.208	<.001	.001	3	6
BRCA	RAD51-AS1 →	+0.698	+0.230	<.001	<.001	3	6
BRCA	USP8 →	+0.348	+0.183	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,884 associations by consensus.

UBE3A vs RTF1 — LSCC

Explore this scatter interactively →