UBE3A

Across TCGA patient cohorts, UBE3A protein abundance is significantly associated with the protein abundance of many other proteins, with 17,489 significant associations in total. GBM shows the largest number of these associations.

The most reproducible UBE3A-associated proteins across cancer lineages are RTF1, SRP14, and TP53BP1. Each is linked with UBE3A in more than 7 cancer types. Because this analysis shows association rather than direction, both UBE3A-to-partner and partner-to-UBE3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UBE3A versus RTF1 in GBM, with a Pearson correlation of 0.64.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3A→partner) and Y-score (partner→UBE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RTF1 →	+0.318	+0.193	<.001	<.001	3	7
GBM	SRP14 →	+0.328	+0.166	<.001	<.001	3	7
COAD	TP53BP1 →	+0.319	+0.213	<.001	<.001	3	7
LSCC	TP53BP1_S500 →	+0.539	+0.235	<.001	<.001	2	8
GBM	FES →	-0.422	-0.153	<.001	<.001	3	6
COAD	TP53BP1_S1094 →	+0.402	+0.173	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,489 associations by consensus.

UBE3A vs RTF1 — GBM

Explore this scatter interactively →