UBE3A

Across TCGA patient cohorts, UBE3A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE3A-associated genes across cancer lineages are ASNS, MEK1, and NF2. Each is linked with UBE3A in more than 3 cancer types. Because this analysis shows association rather than direction, both UBE3A-to-partner and partner-to-UBE3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by UBE3A-low versus UBE3A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3A→partner) and Y-score (partner→UBE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.752	+2.178	<.001	.035	3	4
UCEC	MEK1 →	+0.296	+1.736	.007	.006	3	2
COAD	NF2 →	+0.192	+2.178	.035	.035	3	2
COAD	Cyclin-E2 →	+0.243	+3.025	.026	.018	3	2
UCEC	ER-alpha →	+0.501	+1.362	.043	.034	3	2
UCEC	FoxM1 →	+0.167	+1.321	.032	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ASNS by UBE3A expression — COAD

Explore this box plot interactively →