UBE3A

Across TCGA cell cohorts, UBE3A mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE3A-associated genes across cancer lineages are CELA3B, MTRNR2L10, and CARTPT. Each is linked with UBE3A in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE3A-to-partner and partner-to-UBE3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA3B grouped by UBE3A-low versus UBE3A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3A→partner) and Y-score (partner→UBE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CELA3B →	+0.109	+4.169	<.001	.008	3	2
CNS	MTRNR2L10 →	+0.010	+4.772	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	CARTPT →	+0.045	+3.510	<.001	.007	3	2
BREAST	PROP1 →	+0.084	+4.115	.002	.002	3	2
LUNG_NSCLC_LUSC	SMIM23 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	EXOC1L →	+0.063	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

CELA3B by UBE3A expression — CNS

Explore this box plot interactively →