UBE2W

Across TCGA patient cohorts, UBE2W mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2W-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and INPP4B. Each is linked with UBE2W in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2W-to-partner and partner-to-UBE2W results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UBE2W-low versus UBE2W-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2W→partner) and Y-score (partner→UBE2W) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.331	-2.584	<.001	.001	3	1
UCEC	eIF4E →	+0.172	+1.678	.033	.023	3	1
UCEC	INPP4B →	-0.258	-3.321	.038	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-2.074	.002	.005	3	1
UCEC	JNK2 →	+0.176	+2.584	.020	.001	3	1
UCEC	Ku80 →	+0.231	+1.691	.010	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by UBE2W expression — UCEC

Explore this box plot interactively →