UBE2W

Across TCGA pan-cancer cohorts, UBE2W RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UBE2W’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2W RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2W is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where UBE2W tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2W RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.998	<.001	12	view →
LIHC	Male	II,III,IV	+0.785	<.001	8	view →
STAD	All	II,III,IV	+0.711	<.001	6	view →
BRCA	All	II,III,IV	+0.485	<.001	6	view →
KIRC	Male	All	−0.311	<.001	6	view →
LUAD	Male	All	+0.525	<.001	5	view →
KICH	Female	All	−0.887	<.001	4	view →
CHOL	Female	All	+1.566	<.001	3	view →
READ	All	III,IV	+0.659	.013	2	view →
ESCA	Female	All	+0.449	.002	2	view →
COAD	All	II,III,IV	+0.310	.022	2	view →
THCA	All	All	−0.179	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UBE2W–HNSC

Open the HNSC breakdown →