UBE2W

Across TCGA cell cohorts, UBE2W RNA expression is significantly associated with the go_rna of many other GO terms, with 3,583 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UBE2W-associated GO terms across cancer lineages are Negative regulation of protein localization to centrosome, Protein modification by small protein removal, and Golgi organization. Each is linked with UBE2W in more than 13 cancer types. Because this analysis shows association rather than direction, both UBE2W-to-partner and partner-to-UBE2W results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to centrosome grouped by UBE2W-low versus UBE2W-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2W→partner) and Y-score (partner→UBE2W) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of protein localization to centrosome →	+0.174	+0.884	<.001	.002	3	14
LUNG_NSCLC_LUSC	Protein modification by small protein removal →	+0.056	+0.780	.009	.007	3	13
OVARY	Golgi organization →	+0.055	+0.658	<.001	.002	3	13
STOMACH	Cellular response to misfolded protein →	+0.104	+0.877	<.001	<.001	3	13
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.099	+0.901	<.001	.001	2	13
LIVER	Synaptic vesicle lumen acidification →	+0.156	+0.503	.001	.004	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,583 associations by consensus.

Negative regulation of protein localization to centrosome by UBE2W expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →