UBE2U

Across TCGA patient cohorts, UBE2U mutation is significantly associated with the RNA expression of many other genes, with 577 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2U-associated genes across cancer lineages are LINC02548, RN7SL92P, and TMEM251. Each is linked with UBE2U in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2U-to-partner and partner-to-UBE2U results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02548 grouped by UBE2U-low versus UBE2U-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2U→partner) and Y-score (partner→UBE2U) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02548 →	+0.110	+4.392	.003	.006	3	2
LUSC	RN7SL92P →	+0.412	+4.067	<.001	.001	3	2
UCEC	TMEM251 →	+0.651	+3.191	.005	.009	3	1
UCEC	CD8A →	+1.143	+3.480	.003	.002	3	1
UCEC	DPH3 →	+0.577	+3.470	.002	.003	3	1
UCEC	CXCL13 →	+2.506	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

LINC02548 by UBE2U expression — COAD

Explore this box plot interactively →