UBE2U

Across TCGA pan-cancer cohorts, UBE2U RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated UBE2U data layer compared with 2 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher UBE2U RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE2U expression acts as an unfavorable survival marker, although some lineages such as MESO and CHOL show a favorable association.

SCLC, READ, and MESO are the cancer types where UBE2U RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Tertile	All	0.203	0.649	<.001	45	view →
READ	OS	Tertile	III,IV	0.111	0.890	<.001	27	view →
MESO	DFS	Median	II,III,IV	0.726	0.174	<.001	27	view →
ACC	DFS	Tertile	III,IV	0.312	0.727	.002	18	view →
PAAD	OS	Tertile	All	0.221	0.590	.005	15	view →
COAD	DFS	Tertile	II,III,IV	0.485	0.668	.018	15	view →
UCEC	DFS	Quartile	All	0.459	0.721	.002	12	view →
KICH	DFS	Quartile	II,III,IV	0.486	0.918	.021	12	view →
CHOL	OS	Median	All	0.846	0.308	.014	9	view →
TGCT	DFS	Median	All	0.907	0.758	.026	8	view →
KIRP	DFS	Quartile	IV	0.050	0.687	.024	7	view →
LUAD	OS	Quartile	All	0.878	0.793	.005	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

UBE2U–SCLC (DFS)

Open the SCLC breakdown →