UBE2U

Across TCGA patient cohorts, UBE2U mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2U-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and STAT3_pY705. Each is linked with UBE2U in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2U-to-partner and partner-to-UBE2U results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by UBE2U-low versus UBE2U-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2U→partner) and Y-score (partner→UBE2U) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.246	-3.169	.007	.019	3	1
UCEC	Notch1 →	+0.304	+2.820	<.001	.035	3	1
UCEC	STAT3_pY705 →	-0.538	-2.999	<.001	.035	3	1
UCEC	Bax →	+0.400	+3.009	.002	.019	3	1
UCEC	PCNA →	+0.376	+3.169	.001	.020	1	2
UCEC	Rab25 →	-0.763	-3.000	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by UBE2U expression — UCEC

Explore this box plot interactively →