UBE2Q2

Across TCGA patient cohorts, UBE2Q2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2Q2-associated genes across cancer lineages are eIF4E, FoxM1, and ACVRL1. Each is linked with UBE2Q2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2Q2-to-partner and partner-to-UBE2Q2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by UBE2Q2-low versus UBE2Q2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2Q2→partner) and Y-score (partner→UBE2Q2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.211	+3.807	.026	<.001	3	1
UCEC	FoxM1 →	+0.420	+3.807	<.001	<.001	3	1
UCEC	ACVRL1 →	-0.201	-2.439	.001	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.223	-3.169	.003	.019	3	1
UCEC	JNK2 →	+0.211	+2.000	.018	.032	3	1
UCEC	Ku80 →	+0.256	+2.013	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by UBE2Q2 expression — UCEC

Explore this box plot interactively →