UBE2Q2

Across TCGA pan-cancer cohorts, UBE2Q2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of UBE2Q2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2Q2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2Q2 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where UBE2Q2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2Q2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.656	<.001	12	view →
THCA	Male	All	−0.637	<.001	10	view →
LIHC	Female	II,III,IV	+1.805	<.001	9	view →
CHOL	Male	All	+2.940	<.001	5	view →
BRCA	All	II,III,IV	+0.184	.012	4	view →
LUAD	Female	III,IV	−0.693	.017	1	view →
LUSC	All	III,IV	−0.550	.037	1	view →
LUAD	Male	II,III,IV	+0.417	.024	1	view →
KIRP	All	All	+0.325	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

UBE2Q2–HNSC

Open the HNSC breakdown →