UBE2Q2

Across TCGA cell cohorts, UBE2Q2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBE2Q2-associated genes across cancer lineages are MYL2, PRKAG3, and OR6B3. Each is linked with UBE2Q2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2Q2-to-partner and partner-to-UBE2Q2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL2 grouped by UBE2Q2-low versus UBE2Q2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2Q2→partner) and Y-score (partner→UBE2Q2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYL2 →	+0.538	+4.152	<.001	.009	3	1
BLOOD_Leukemia	PRKAG3 →	+0.024	+4.551	.001	.004	3	1
BLOOD_Leukemia	OR6B3 →	+0.019	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TRIM49B →	+0.140	+4.874	<.001	.002	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.010	+4.551	.001	.004	3	1
BLOOD_Leukemia	SPP2 →	+0.131	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MYL2 by UBE2Q2 expression — BLOOD_Leukemia

Explore this box plot interactively →