UBE2O

Across TCGA pan-cancer cohorts, UBE2O mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBE2O data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UBE2O mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE2O expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where UBE2O mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.203	0.733	.004	20	view →
CCRCC	OS	Quartile	II,III,IV	0.744	1.000	.030	7	view →
UCEC	DFS	Quartile	All	0.813	0.966	.019	6	view →
LUAD	DFS	Quartile	All	0.997	0.837	.006	4	view →
HNSC	DFS	Quartile	All	0.769	0.505	.011	4	view →
GBM	DFS	Quartile	All	0.801	0.669	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBE2O–PDAC (DFS)

Open the PDAC breakdown →