UBE2N

Across TCGA pan-cancer cohorts, UBE2N mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UBE2N data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UBE2N mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UBE2N expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where UBE2N mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.987	0.747	.001	32	view →
GBM	OS	Quartile	All	1.000	0.772	.003	6	view →
CCRCC	DFS	Tertile	III,IV	0.887	0.198	.024	5	view →
PDAC	OS	Quartile	III,IV	0.601	0.186	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UBE2N–LSCC (OS)

Open the LSCC breakdown →