UBE2N

Across TCGA pan-cancer cohorts, UBE2N RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of UBE2N’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where UBE2N RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2N is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, LIHC, and HNSC are the cancer types where UBE2N tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2N RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.432	<.001	10	view →
LIHC	Male	III,IV	+1.018	<.001	9	view →
HNSC	Male	All	+0.445	<.001	8	view →
THCA	All	II,III,IV	−0.393	<.001	8	view →
KICH	Female	All	−0.889	<.001	7	view →
BRCA	All	III,IV	+0.639	<.001	6	view →
LUSC	Female	All	+0.584	<.001	6	view →
STAD	All	II,III,IV	+0.570	<.001	6	view →
COAD	All	II,III,IV	+0.500	<.001	6	view →
CHOL	Male	All	+1.890	<.001	5	view →
ESCA	All	All	+0.858	.003	4	view →
UCEC	All	III,IV	+0.577	.030	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

UBE2N–BLCA

Open the BLCA breakdown →