UBE2N

Across TCGA patient cohorts, UBE2N mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2N-associated genes across cancer lineages are EGFR_pY1068, EGFR, and MAPK_pT202_Y204. Each is linked with UBE2N in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2N-to-partner and partner-to-UBE2N results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UBE2N-low versus UBE2N-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2N→partner) and Y-score (partner→UBE2N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.229	-3.584	.020	.002	3	1
UCEC	EGFR →	-0.135	-3.143	.032	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.579	-3.308	.001	.009	3	1
UCEC	MEK1_p_S217_S221 →	-0.318	-2.000	.002	.010	3	1
UCEC	Notch1 →	+0.120	+3.469	.029	.002	3	1
UCEC	PDCD4 →	-0.485	-2.575	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by UBE2N expression — UCEC

Explore this box plot interactively →