UBE2L6

Across TCGA patient cohorts, UBE2L6 mutation is significantly associated with the RNA expression of many other genes, with 1,629 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2L6-associated genes across cancer lineages are RNU4ATAC5P, GTF2I, and MIR378H. Each is linked with UBE2L6 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2L6-to-partner and partner-to-UBE2L6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4ATAC5P grouped by UBE2L6-low versus UBE2L6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2L6→partner) and Y-score (partner→UBE2L6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU4ATAC5P →	+0.303	+4.771	<.001	.006	3	2
UCEC	GTF2I →	+0.833	+3.595	.009	.001	3	1
UCEC	MIR378H →	+0.630	+3.342	.009	<.001	3	1
UCEC	MIR3928 →	+0.417	+2.631	<.001	.007	3	1
UCEC	MIR3153 →	+1.118	+2.986	<.001	.002	3	1
UCEC	MIR5188 →	+0.729	+2.328	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,629 associations by consensus.

RNU4ATAC5P by UBE2L6 expression — SKCM

Explore this box plot interactively →