UBE2L2

Across TCGA patient cohorts, UBE2L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,118 significant associations in total. STAD shows the largest number of these associations.

The most reproducible UBE2L2-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle, Sex differentiation, and Regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Each is linked with UBE2L2 in more than 12 cancer types. Because this analysis shows association rather than direction, both UBE2L2-to-partner and partner-to-UBE2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle grouped by UBE2L2-low versus UBE2L2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2L2→partner) and Y-score (partner→UBE2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of mitotic cell cycle →	+0.059	+0.183	.002	<.001	2	13
ESCA	Sex differentiation →	+0.050	+0.180	<.001	<.001	3	11
ESCA	Regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.076	+0.182	<.001	<.001	3	11
ESCA	Regulation of proteolysis involved in protein catabolic process →	+0.063	+0.181	.002	<.001	3	11
STAD	Signal transduction in response to DNA damage →	+0.060	+0.197	<.001	<.001	3	11
ESCA	Macromolecule methylation →	+0.051	+0.182	.004	<.001	1	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,118 associations by consensus.

Positive regulation of mitotic cell cycle by UBE2L2 expression — ESCA

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