UBE2L2

Across TCGA pan-cancer cohorts, UBE2L2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated UBE2L2 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher UBE2L2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UBE2L2 expression acts as an unfavorable survival marker, although some lineages such as LAML and LIHC show a favorable association.

UVM, UCEC, and PAAD are the cancer types where UBE2L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.488	0.887	<.001	105	view →
UCEC	DFS	Tertile	II,III,IV	0.313	0.565	<.001	90	view →
PAAD	OS	Tertile	All	0.412	0.668	.011	75	view →
CHOL	DFS	Tertile	III,IV	0.031	0.505	.003	72	view →
BRCA	OS	Tertile	II,III,IV	0.536	0.572	.009	36	view →
LUSC	OS	Tertile	III,IV	0.488	0.719	.002	36	view →
CESC	DFS	Tertile	IV	0.121	0.548	.002	36	view →
COAD	OS	Tertile	IV	0.183	0.670	.003	18	view →
BLCA	DFS	Tertile	IV	0.121	0.477	.005	18	view →
ACC	DFS	Tertile	All	0.163	0.596	.023	9	view →
SKCM	OS	Tertile	IV	0.224	0.709	.018	9	view →
GBM	DFS	Median	All	0.189	0.371	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

UBE2L2–UVM (OS)

Open the UVM breakdown →