UBE2K

Across TCGA pan-cancer cohorts, UBE2K mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBE2K data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher UBE2K mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBE2K expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

GBM, UCEC, and LSCC are the cancer types where UBE2K mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.728	0.902	.022	12	view →
UCEC	OS	Median	All	1.000	0.912	.017	8	view →
LSCC	OS	Median	II,III,IV	0.699	0.858	.041	2	view →
LUAD	OS	Quartile	All	0.742	1.000	.024	2	view →
HNSC	OS	Median	III,IV	0.930	0.803	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBE2K–GBM (OS)

Open the GBM breakdown →