UBE2K

Across TCGA pan-cancer cohorts, UBE2K RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of UBE2K’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2K RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2K is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where UBE2K tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2K RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.575	<.001	11	view →
LIHC	Male	All	+0.702	<.001	8	view →
LUAD	Male	II,III,IV	+0.795	<.001	7	view →
THCA	All	All	−0.291	<.001	7	view →
BRCA	All	II,III,IV	+0.501	<.001	6	view →
CHOL	Male	All	+0.973	<.001	5	view →
LUSC	All	II,III,IV	+0.558	<.001	5	view →
STAD	All	II,III,IV	+0.442	.009	5	view →
UCEC	All	III,IV	+0.734	.007	4	view →
BLCA	Male	IV	+0.480	.014	3	view →
KICH	All	All	−0.450	.003	3	view →
PAAD	Male	All	+0.479	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

UBE2K–HNSC

Open the HNSC breakdown →