UBE2K

Across TCGA patient cohorts, UBE2K mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2K-associated genes across cancer lineages are 14-3-3_beta, Ku80, and MEK1. Each is linked with UBE2K in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2K-to-partner and partner-to-UBE2K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by UBE2K-low versus UBE2K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2K→partner) and Y-score (partner→UBE2K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.111	-2.973	.017	.035	3	1
UCEC	Ku80 →	+0.242	+2.598	.028	.006	3	1
UCEC	MEK1 →	+0.465	+2.459	.006	.019	3	1
UCEC	Annexin-1 →	+0.565	+2.341	.021	.019	3	1
UCEC	Tuberin →	+0.318	+2.179	.011	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.569	+3.019	.039	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by UBE2K expression — UCEC

Explore this box plot interactively →