UBE2G1

Across TCGA patient cohorts, UBE2G1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2G1-associated genes across cancer lineages are GAPDH, MSH2, and p70-S6K_pT389. Each is linked with UBE2G1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2G1-to-partner and partner-to-UBE2G1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by UBE2G1-low versus UBE2G1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2G1→partner) and Y-score (partner→UBE2G1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.658	+3.000	.014	.036	3	1
UCEC	MSH2 →	-0.348	-2.990	.002	.036	3	1
UCEC	p70-S6K_pT389 →	-0.245	-3.160	.010	.019	3	1
UCEC	Annexin-1 →	+0.563	+2.321	.033	.035	3	1
UCEC	Shc_pY317 →	-0.228	-3.459	.002	.005	3	1
UCEC	ATM →	-0.616	-3.459	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GAPDH by UBE2G1 expression — UCEC

Explore this box plot interactively →