UBE2E1

Across TCGA patient cohorts, UBE2E1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2E1-associated genes across cancer lineages are FOXO3a_pS318_S321, Heregulin, and ACVRL1. Each is linked with UBE2E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2E1-to-partner and partner-to-UBE2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by UBE2E1-low versus UBE2E1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2E1→partner) and Y-score (partner→UBE2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.183	-3.312	.002	.010	3	1
UCEC	Heregulin →	-0.125	-3.000	.035	.036	3	1
UCEC	ACVRL1 →	-0.138	-2.980	.035	.036	3	1
UCEC	JNK2 →	+0.278	+3.009	.003	.019	3	1
UCEC	PCNA →	+0.349	+3.584	<.001	.002	3	1
UCEC	Rab11 →	-0.140	-2.459	.046	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FOXO3a_pS318_S321 by UBE2E1 expression — UCEC

Explore this box plot interactively →