UBE2D3

Across TCGA patient cohorts, UBE2D3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2D3-associated genes across cancer lineages are STAT3_pY705, Tuberin, and ASNS. Each is linked with UBE2D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2D3-to-partner and partner-to-UBE2D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by UBE2D3-low versus UBE2D3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2D3→partner) and Y-score (partner→UBE2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.430	-1.807	<.001	.027	3	2
UCEC	Tuberin →	+0.363	+3.710	.001	<.001	3	2
UCEC	ASNS →	+0.659	+3.584	<.001	.002	3	2
UCEC	eIF4G →	+0.324	+2.321	.011	.006	3	1
UCEC	A-Raf_pS299 →	-0.143	-3.700	.003	.001	3	1
UCEC	ACC_pS79 →	+0.318	+1.807	.026	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

STAT3_pY705 by UBE2D3 expression — UCEC

Explore this box plot interactively →