UBE2D3

Across TCGA pan-cancer cohorts, UBE2D3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of UBE2D3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UBE2D3 RNA is repressed in tumor relative to normal tissue. In most cancer types UBE2D3 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, HNSC, and UCEC are the cancer types where UBE2D3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2D3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.505	<.001	10	view →
HNSC	All	All	+0.317	<.001	10	view →
UCEC	All	All	−0.548	.003	4	view →
KICH	All	All	−0.530	.001	4	view →
BLCA	Female	All	−0.408	.021	4	view →
LIHC	All	II,III,IV	+0.406	.003	4	view →
CHOL	All	All	+0.758	<.001	3	view →
LUAD	Female	II,III,IV	−0.356	.002	3	view →
LUSC	All	All	−0.205	.007	3	view →
READ	All	All	−0.442	.010	2	view →
ESCA	All	All	+0.451	.040	1	view →
KIRP	Male	All	−0.314	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

UBE2D3–THCA

Open the THCA breakdown →