UBE2D1

Across TCGA patient cohorts, UBE2D1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2D1-associated genes across cancer lineages are JNK2, PDCD4, and Rad50. Each is linked with UBE2D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2D1-to-partner and partner-to-UBE2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by UBE2D1-low versus UBE2D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2D1→partner) and Y-score (partner→UBE2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.277	+2.179	.002	.034	3	1
UCEC	PDCD4 →	-0.575	-2.999	.008	.035	3	1
UCEC	Rad50 →	-0.234	-2.986	.038	.035	3	1
UCEC	Tuberin →	+0.338	+2.179	.007	.034	3	1
UCEC	VEGFR2 →	+0.338	+1.887	.014	.031	3	1
UCEC	C-Raf →	+0.194	+2.999	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by UBE2D1 expression — UCEC

Explore this box plot interactively →